Abstract
Interferon regulatory factors (IRFs) regulate the transcription of both interferon-inducible genes and interferons themselves. Along with the N-terminal, DNA-binding, winged-helix domain, most IRFs contain the C-terminal domains that are shown to be related to the C-terminal domains in the proteins of the Smad family that mediate transcription activation in the transforming growth factor response pathway. Comparison of the IRF-Smad alignment to the known three-dimensional structure of human tumor suppressor Smad4 suggests that a conserved loop, equivalent to Loop 3 in Smad 4, is a determinant of protein-protein interaction in IRFs.
MeSH terms
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Amino Acid Sequence
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Conserved Sequence
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / genetics
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Humans
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Interferon Regulatory Factor-1
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Interferons / genetics*
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Interferons / metabolism
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Molecular Sequence Data
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Phosphoproteins / chemistry*
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Phosphoproteins / genetics
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Protein Structure, Secondary
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Sequence Alignment
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Smad4 Protein
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Trans-Activators / chemistry*
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Trans-Activators / genetics
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Transcription Factors / chemistry*
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Transcription Factors / genetics
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Transcriptional Activation*
Substances
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DNA-Binding Proteins
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IRF1 protein, human
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Interferon Regulatory Factor-1
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Phosphoproteins
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SMAD4 protein, human
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Smad4 Protein
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Trans-Activators
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Transcription Factors
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Interferons