Heterozygote advantage of the MTHFR gene in patients with neural-tube defect and their relatives

Lancet. 1998 May 23;351(9115):1554-5. doi: 10.1016/s0140-6736(05)61119-1.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abortion, Spontaneous / genetics
  • Alleles
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetic Variation / genetics
  • Genotype
  • Heterozygote*
  • Homozygote
  • Humans
  • Male
  • Methylenetetrahydrofolate Dehydrogenase (NAD+)
  • Mutation / genetics
  • Neural Tube Defects / enzymology
  • Neural Tube Defects / genetics*
  • Oxidoreductases / genetics*
  • Pregnancy
  • Sex Factors
  • Spinal Dysraphism / enzymology
  • Spinal Dysraphism / genetics

Substances

  • Oxidoreductases
  • Methylenetetrahydrofolate Dehydrogenase (NAD+)