Chest
Clinical InvestigationsCOPDAssociation of Tumor Necrosis Factor-α Gene Promoter Polymorphism With Low Attenuation Areas on High-Resolution CT in Patients With COPD
Section snippets
Subjects
The subjects consisted of 84 patients with cigarette smoking-related COPD who underwent HRCT, recruited from the Respiratory Outpatient Department of Chiba University Hospital and affiliated hospitals. COPD was diagnosed on the basis of history, physical examination, and spirometric data, according to the American Thoracic Society guidelines.18 Pulmonary function tests were performed to determine FVC and FEV1 using a standard spirometer (Fudac-60; Fukuda Denshi; Tokyo, Japan) in the standing
Results
Fifty-three men and 31 women were recruited to the cigarette smoking-related COPD group. Age, smoking history, and pulmonary function data of COPD patients are summarized in Table 1. COPD patients were classified by the median visual score: those with a visual score ≥ 11 and those with a visual score < 11. No significant differences were observed in age or smoking history between patients with a visual score ≥ 11 and patients with a visual score < 11. FEV1/FVC and FEV1 percent predicted were
Discussion
In the present study, we compared the frequency of a polymorphism in the promoter region of the TNF-α gene (designated TNF-α-308*1/2) in Japanese patients with cigarette smoking-related COPD showing severe (visual score ≥ 11) and mild or moderate emphysematous changes (visual score < 11). The ages and smoking habits were similar between these two groups. The frequency of the TNF-α-308*2 allele tended to be higher in patients with a visual score ≥ 11 than in patients with a visual score < 11 (p
ACKNOWLEDGMENT
We thank Drs. Katsutoshi Nakayama and Mutsuo Yamaya, Department of Geriatric Medicine, Tohoku University School of Medicine for technical assistance.
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Cited by (76)
TNF-α inhibitors in asthma and COPD: We must not throw the baby out with the bath water
2010, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :TNF-α has been shown to correlate with body mass index (BMI) and cigarette smoke exposure [71,72] and other inflammatory mediators [73] in COPD. A polymorphism of the promoter region of the TNF-α gene has been implicated in the occurrence, severity, and mortality risk of COPD [74–76]. Intriguingly, TNF-α levels in sputum increase significantly during acute exacerbations of COPD [77,78].
Genetics of COPD and emphysema
2009, ChestThe Neutrophil and Its Special Role in Chronic Obstructive Pulmonary Disease
2009, Asthma and COPDCT scanning-based phenotypes vary with ADRB2 polymorphisms in chronic obstructive pulmonary disease
2009, Respiratory MedicineCitation Excerpt :Genetic variability in COPD patients might explain persistent inflammation and the varying degrees of involvement of airway and parenchyma. To date, there have been several reports regarding the association of CT phenotypes and particular genotypes.7–9 The phenotypes associated with particular genes are mainly the severity of emphysema and emphysema distribution.
This study was in part supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, and Culture, and a research grant by Respiratory Failure Research Group from the Ministry of Health and Welfare, Japan.