Alimentary TractInterleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma☆,☆☆
Section snippets
Tissue material
We evaluated, in a case-control study, the IL-1B-511 biallelic and IL-1RN penta-allelic variable number of tandem repeats (VNTR) polymorphisms. The study was performed in a control group of blood donors (n = 220) and in a series of patients with gastric carcinoma (n = 152). Both sample groups were collected in northern Portugal. In the control group, the average age was 38.3 ± 11.6 years (range, 19–61 years) and the male:female ratio was 1.6:1. In the gastric carcinoma group, the average age
IL-1B-511C/T
In the control population, the IL-1B-511C/T genotypes (Figure 1A) showed no evidence of deviation from Hardy–Weinberg equilibrium (P = 0.1; Table 1).Comparison of genotype
Discussion
We assessed the association between the IL-1B-511C/T and IL-1RN VNTR polymorphisms and the risk of gastric carcinoma in a population from northern Portugal. In Portugal, the incidence and mortality rates of gastric carcinoma are among the highest in the world and in the north of the country it has been shown that H. pylori infects more than 80% of the asymptomatic adult population and more than 95% of relatives of patients with gastric carcinoma. In a population of distinct geographical
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Address requests for reprints to: José Carlos Machado, IPATIMUP, Rua Roberto Frias, s/n, 4200 Porto, Portugal. e-mail: [email protected]; fax: (351) 225570799.
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Supported by Fundação para a Ciência e a Tecnologia (FCT) (grant 35374/99 Sapiens Proj99) and by Programa Operacional Ciência, Tecnologia e lnovação (POCTI) do Quadro Comunitário de Apoio (QCA) II.