Abstract
As the molecular processes that control mRNA translation and ribosome biogenesis in the eukaryotic cell are extremely complex and multilayered, their deregulation can in principle occur at multiple levels, leading to both disease and cancer pathogenesis. For a long time, it was speculated that disruption of these processes may participate in tumorigenesis, but this notion was, until recently, solely supported by correlative studies. Strong genetic support is now being accrued, while new molecular links between tumor-suppressive and oncogenic pathways and the control of protein synthetic machinery are being unraveled. The importance of aberrant protein synthesis in tumorigenesis is further underscored by the discovery that compounds such as Rapamycin, known to modulate signaling pathways regulatory of this process, are effective anticancer drugs. A number of fundamental questions remain to be addressed and a number of novel ones emerge as this exciting field evolves.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bader AG and Vogt PK . (2004). Oncogene, 23, 3145–3150.
Bernardi R and Pandolfi PP . (2003). Nat. Med., 9, 24–25.
Bertwistle D, Sugimoto M and Sherr CJ . (2004). Mol. Cell. Biol., 24, 985–996.
Clemens MJ . (2004). Oncogene, 23, 3180–3188.
De Benedetti A and Graff JR . (2004). Oncogene, 23, 3189–3199.
Fingar DC and Blenis J . (2004). Oncogene, 23, 3151–3171.
Holland EC, Pandolfi PP, Sonenberg N and Thomas G . (2004). Oncogene, 23, 3138–3144.
Iritani BM and Eisenman RN . (1998). Proc. Natl. Acad. Sci. USA, 96, 13180–13185.
Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R and Zhang Y . (2003). Mol. Cell, 12, 1151–1164.
Lazaris-Karatzas A, Montine KS and Sonenberg N . (1990). Nature, 345, 544–547.
Mamane Y, Petroulakis E, Rong L, Yoshida K, Ler LW and Sonenberg N . (2004). Oncogene, 23, 3172–3179.
Perrotti D and Calabretta B . (2004). Oncogene, 23, 3222–3229.
Pianese G . (1896). Beitr. Pathol. Anat. Allgem. Pathol., 142, 1–193.
Piazza F, Gurrieri C and Pandolfi PP . (2001). Oncogene, 20, 7216–7222.
Rajasekhar VK and Holland EC . (2004). Oncogene, 23, 3248–3264.
Redner RL, Rush EA, Faas S, Rudert WA and Corey SJ . (1996). Blood, 87, 882–886.
Rosenwald IB . (2004). Oncogene, 23, 3230–3247.
Ruggero D, Grisendi S, Piazza D, Rego E, Mari F, Cordon-Cardo C and Pandolfi PP . (2003). Science, 299, 259–262.
Ruggero D, Motanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C and Pandolfi PP . (2004). Nature Med., in press.
Ruggero D and Pandolfi PP . (2003). Nat. Rev. Cancer, 3, 175–192.
Savkur RS and Olson MO . (1998). Nucleic Acids Res., 26, 4508–4515.
Schmidt EV . (2004). Oncogene, 23, 3217–3221.
Stoneley M and Willis AE . (2004). Oncogene, 23, 3200–3207.
White RJ . (2004). Oncogene, 23, 3208–3216.
Acknowledgements
We would like to thank the members of the Molecular and Developmental Biology (MADB) lab and, in particular, the present and past members of the team working on deregulated translational control in tumorigenesis: Davide Ruggero, Silvia Grisendi, Li Ma, Lorenzo Montanaro, Wei Xu. We are grateful to Linda DiSantis for coordinating this whole special issue and for editing this introductory chapter as well as the manuscript by Holland et al. This work is supported by NCI grants to PPP.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pandolfi, P. Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age. Oncogene 23, 3134–3137 (2004). https://doi.org/10.1038/sj.onc.1207618
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1207618
Keywords
This article is cited by
-
Ribosomal protein L22-like1 (RPL22L1) mediates sorafenib sensitivity via ERK in hepatocellular carcinoma
Cell Death Discovery (2022)
-
Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation
Cell Communication and Signaling (2019)
-
Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells
Molecular and Cellular Biochemistry (2018)
-
A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment
Cell Death & Disease (2016)
-
EPMA position paper in cancer: current overview and future perspectives
EPMA Journal (2015)