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No association with the neuregulin 1 haplotype to Japanese schizophrenia

Molecular Psychiatry volume 9, pages 126–127 (2004)Cite this article

SIR—Schizophrenia is a complex genetic disorder and has heritability of around 80%. The pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on reports of an excess of adverse events during the pre- and perinatal periods, the presence of cognitive and behavioral signs during childhood and adolescence, and the lack of evidence of a neurodegenerative process in most individuals with schizophrenia.1

To date, studies of the association between schizophrenia and genes coding for neurodevelopmental role has been published.2 Recently, it has been reported that genetic variants around the gene neuregulin 1 (NRG1) are associated with schizophrenia in an Icelandic sample.3 The replications of this finding have been reported independently from Scottish population4 and Caucasians born in UK and Ireland.5 The at-risk haplotype was found to be over-represented in schizophrenics compared to controls.

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Authors and Affiliations

  1. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, 470-1192, Aichi, Japan

    N Iwata, T Suzuki, M Ikeda, T Kitajima, Y Yamanouchi & N Ozaki

  2. Department of Psychiatry, Nagoya University Graduated School of Medicine, Nagoya, Japan

    M Ikeda & T Inada

Authors
  1. N Iwata
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  2. T Suzuki
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  3. M Ikeda
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  4. T Kitajima
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  5. Y Yamanouchi
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  6. T Inada
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  7. N Ozaki
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Corresponding author

Correspondence to N Iwata.

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Iwata, N., Suzuki, T., Ikeda, M. et al. No association with the neuregulin 1 haplotype to Japanese schizophrenia. Mol Psychiatry 9, 126–127 (2004). https://doi.org/10.1038/sj.mp.4001456

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