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  • Original Research Article
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Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33

Molecular Psychiatry volume 9, pages 87–92 (2004)Cite this article

A Corrigendum to this article was published on 26 July 2004

Abstract

Markers near the nested genes G72 and G30 on chromosome 13q33 have been implicated in the etiology of schizophrenia and, recently, bipolar affective disorder (BPAD). Hattori et al (2003) reported that single-nucleotide polymorphisms (SNPs) near the G72/G30 locus were associated with BPAD in a sample of 22 pedigrees, and that SNP haplotypes were associated in a second, larger sample of triads. The present study attempts to replicate this finding in an independent case–control sample. Six SNPs near the G72/G30 locus, including the most strongly associated markers in the previous study, were tested in 139 cases and 113 ethnically matched controls. Significant association was detected between BPAD and two adjacent SNPs (smallest P=0.007; global P=0.024). Haplotype analysis produced additional support for association (smallest P=0.004; global P=0.004). Analysis of 31 unlinked microsatellite markers detected no population stratification in the cases or controls studied. Although the associated alleles and haplotypes differ from those previously reported, these new results provide further evidence, in an independent sample, for an association between BPAD and genetic variation in the vicinity of the genes G72 and G30.

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Acknowledgements

This study was supported in part by Young Investigator Awards from the National Association for Research on Schizophrenia and Depression (Y-SC and TGS) and by the National Institute of Mental Health Intramural Research Program (FJM and SDD). Sample collection was supported by grants from the National Institute of Mental Health, The Charles A Dana Foundation, and the Ted and Vada Stanley Foundation. We thank Elliot S Gershon for kindly making his manuscript available to us in advance of publication; Sylvia G Simpson, Dean F MacKinnon, and Susan Folstein for contributing to the clinical assessments and diagnoses; Tu Nguyen for assisting with data management; and the family volunteers, without whom this work would not have been possible.

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Authors and Affiliations

  1. Department of Human Genetics, The University of Chicago, Chicago, IL, USA

    Y-S Chen & N J Cox

  2. Department of Health and Human Services, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA

    N Akula, S D Detera-Wadleigh, T G Schulze, J Thomas & F J McMahon

  3. Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany

    T G Schulze

  4. Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    J B Potash, J R DePaulo & M G McInnis

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  1. Y-S Chen
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Correspondence to F J McMahon.

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Chen, YS., Akula, N., Detera-Wadleigh, S. et al. Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. Mol Psychiatry 9, 87–92 (2004). https://doi.org/10.1038/sj.mp.4001453

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