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The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

International Journal of Obesity volume 24, pages 522–524 (2000)Cite this article

Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P=0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

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Acknowledgements

We are deeply grateful for the cooperation of the SAFHS participants. This work was supported by National Institutes of Health research grants PO1-HL45522 and RO1-AR43351. Support for the Frederic C. Bartter General Clinical Research Center was through Clinical National Institutes of Health Grant MO1-RR-01346.

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Authors and Affiliations

  1. Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, 78245, TX, USA

    SA Cole, BD Mitchell, W-C Hsueh, P Pineda, AG Comuzzie, J Blangero & JE Hixson

  2. Johns Hopkins University School of Medicine; Geriatrics Center,

    BA Beamer

  3. Geriatrics Center, 5505 Hopkins Bayview Circle, Baltimore, 21224, MD, USA

    BA Beamer

  4. University of Maryland School of Medicine and the Baltimore Veterans Administration Medical Center Geriatrics Research and Education Clinical Center, 725 West Lombard St, Baltimore, 21201, MD, USA

    AR Shuldiner

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  1. SA Cole
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Correspondence to SA Cole.

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Cole, S., Mitchell, B., Hsueh, WC. et al. The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. Int J Obes 24, 522–524 (2000). https://doi.org/10.1038/sj.ijo.0801210

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