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Mannose-binding lectin and its genetic variants

Abstract

Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of the complement system and is of importance for host defence. Common variant alleles situated both in the promoter and structural region of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variation in MBL serum concentration influences the susceptibility to and the course of different types of infections, autoimmune, metabolic and cardiovascular diseases, but this is still a subject of debate. The fact that these genetic variations are very frequent indicates a dual role for MBL in host defence. In this survey, we summarize the current molecular understanding of human MBL genetics.

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Acknowledgements

We wish to thank the Danish Medical Research Council, The Danish Council for Development Research, The Novo Nordisk Research Foundation, The Danish Rheumatism Association, Health Insurance Denmark Research Foundation, Copenhagen Hospital Corporation Research Foundation, Rigshospitalet, EU and CONCYTEC-Peru for financial support over the years.

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Garred, P., Larsen, F., Seyfarth, J. et al. Mannose-binding lectin and its genetic variants. Genes Immun 7, 85–94 (2006). https://doi.org/10.1038/sj.gene.6364283

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