Abstract
Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there and what function do they serve in this location? Recent advances have provided tantalizing hints to the answers to these questions, and hold the key to identifying a new mode of signal transduction.
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Acknowledgements
We apologize to the many authors whose works were not cited here owing to both space limitations and the focus on the EGFR family. Our work was supported by grants from the National Institutes of Health (NIGMS and NCI), the Veterans Administration and the Swiss National Science Foundation.
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Wells, A., Marti, U. Signalling shortcuts: cell-surface receptors in the nucleus?. Nat Rev Mol Cell Biol 3, 697–702 (2002). https://doi.org/10.1038/nrm905
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DOI: https://doi.org/10.1038/nrm905
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