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References
Ramensky, V., Bork, P. & Sunyaev, S. Nucleic Acids Res. 30, 3894–3900 (2002).
Schmidt, S. et al. PLoS Genet. 4, e1000281 (2008).
Capriotti, E., Calabrese, R. & Casadio, R. Bioinformatics 22, 2729–2734 (2006).
Ng, P.C. & Henikoff, S. Nucleic Acids Res. 31, 3812–3814 (2003).
Bromberg, Y., Yachdav, G. & Rost, B. Bioinformatics 24, 2397–2398 (2008).
Yue, P., Melamud, E. & Moult, J. BMC Bioinformatics 7, 166 (2006).
Acknowledgements
We thank Y. Bromberg for help with the SNAP analysis. V.E.R. acknowledges support by the Russian Academy of Sciences Program in Molecular and Cellular Biology. This work was supported by the US National Institutes of Health (R01 GM078598 and in part by R01 MH084676).
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Supplementary Figures 1–4, Supplementary Tables 1–2, Supplementary Methods (PDF 646 kb)
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Adzhubei, I., Schmidt, S., Peshkin, L. et al. A method and server for predicting damaging missense mutations. Nat Methods 7, 248–249 (2010). https://doi.org/10.1038/nmeth0410-248
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DOI: https://doi.org/10.1038/nmeth0410-248
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