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Hemochromatosis: The genetic disorder of the twenty–first century

Nature Medicine volume 2, pages 394–395 (1996)Cite this article

Recent molecular genetics and public health efforts are aimed at understanding, detecting and treating this common but underrecognized disorder.

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References

  1. Edwards, C.Q. et al. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N. Engl. J. Med. 318, 1355–1362 (1988).

    Article  CAS  Google Scholar 

  2. Witte, D.L. et al. Practice parameter for hereditary hemochromatosis. Clin. Chim. Acta (in the press).

  3. McLaren, C.E. et al. Prevalence of heterozygotes for hemochromatosis in the white population of the United States. Blood 86, 2021–2027 (1995).

    CAS  PubMed  Google Scholar 

  4. Barton, J.C. et al. Blood lead concentrations in hereditary hemochromatosis. J. Lab. Clin. Med. 124, 193–198 (1994).

    CAS  PubMed  Google Scholar 

  5. Rothenberg, B.E. & Voland, J.R. β2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc. Natl. Acad. Sci. USA 93, 1529–1534 (1996).

    Article  CAS  Google Scholar 

  6. Brock, J.H. Iron in infection, immunity, inflammation, and neoplasia. in Iron Metabolism in Health and Disease. (eds. Brock, J.H., Halliday, J.W., Pippard, M.J. & Powell, L.W.) 353–390 (Saunders, London, 1994).

    Google Scholar 

  7. Gordeuk, V. et al. Iron overload in Africa: Interaction between a gene and dietary iron content. N. Engl. J. Med. 326, 95–100 (1992).

    Article  CAS  Google Scholar 

  8. Barton, J.C., Edwards, C.Q., Bertoli, L.F., Shroyer, T.W. & Hudson, S.L. Iron overload in African Americans. Am. J. Med. 99, 616–623 (1995).

    Article  CAS  Google Scholar 

  9. Eason, E.J., Adams, P.C., Aston, C.E. & Searle, J. Familial iron overload with possible autosomal dominant inheritance. Aust. N.Z. J. Med. 20, 226–230 (1990).

    Article  CAS  Google Scholar 

  10. Edwards, C.Q. & Kushner, J.P. Screening for hemochromatosis. N. Engl. J. Med. 328, 1616–1620 (1993).

    Article  CAS  Google Scholar 

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  1. Department of Medicine, Brookwood Medical Center, Birmingham, Alabama, 35209, USA

    James C. Barton & Luigi F. Bertoli

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  1. James C. Barton
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  2. Luigi F. Bertoli
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Barton, J., Bertoli, L. Hemochromatosis: The genetic disorder of the twenty–first century. Nat Med 2, 394–395 (1996). https://doi.org/10.1038/nm0496-394

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