Murr1, a protein linked to copper homeostasis, is shown in a recent Nature paper to inhibit the degradation of IκBα. This unexpected action of Murr1, which blunts both basal and stimulus-coupled activation of the NF-κB transcription factor, is key in making resting CD4 T lymphocytes nonpermissive for HIV infection.
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Greene, W. How resting T cells deMURR HIV infection. Nat Immunol 5, 18–19 (2004). https://doi.org/10.1038/ni0104-18
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DOI: https://doi.org/10.1038/ni0104-18