Abstract
A C→G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS)1. We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.
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Acknowledgements
We thank the MS patients and their families for making this study possible. This work was supported by National Multiple Sclerosis Society (NMSS) grants RG2901 (JRO) and RG2542 (SLH), NIH grants NS26799 (SLH, JRO) and NS32830 (JLH, MAP-V), and the Nancy Davis Foundation. The collection of subjects and all experiments were performed under the approval of the Committee of Human Research at UC San Francisco.
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Barcellos, L., Caillier, S., Dragone, L. et al. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nat Genet 29, 23–24 (2001). https://doi.org/10.1038/ng722
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DOI: https://doi.org/10.1038/ng722
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