Abstract
A variety of maps of the human genome have been constructed, including cloned DNA maps. We have isolated 40 of the 42 Notl sites that exist on the long arm of human chromosome 21, as A Notl linking clones and constructed a complete Notl restriction map spanning the entire region. This map, which provides the most reliable ordering and distance estimation in the region from a pericentromeric locus to the terminus, demonstrates the usefulness of linking clone mapping for analysing human chromosomes.
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Ichikawa, H., Hosoda, F., Arai, Y. et al. A Notl restriction map of the entire long arm of human chromosome 21. Nat Genet 4, 361–366 (1993). https://doi.org/10.1038/ng0893-361
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DOI: https://doi.org/10.1038/ng0893-361
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