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A high resolution deletion map of human chromosome Xp22

Nature Genetics volume 4, pages 272–279 (1993)Cite this article

Abstract

We have developed a 32–interval deletion panel for human chromosome Xp22 spanning about 30 megabases of genomic DNA. DNA samples from 50 patients with chromosomal rearrangements involving Xp22 were tested with 60 markers using a polymerase chain reaction strategy. The ensuing deletion map allowed us to confirm and refine the order of previously isolated and newly developed markers. Our mapping panel will provide the framework for mapping new sequences, for orienting chromosome walks in the region and for projects aimed at isolating genes responsible for diseases mapping to Xp22.

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Authors and Affiliations

  1. Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Laura Schaefer, Giovanni B. Ferrero, Alessandra Grillo, Maria T. Bassi, Martin C. Wapenaar, Huda Y. Zoghbi & Andrea Ballabio

  2. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Elizabeth J. Roth & Huda Y. Zoghbi

  3. Human Genome Center, Baylor College of Medicine, Houston, Texas, 77030, USA

    Huda Y. Zoghbi & Andrea Ballabio

  4. Department of Human Genetics, Leiden University, Leiden, 2333AL, The Netherlands

    Gert-Jan B. van Ommen

  5. Division for Medical Genetics, Harbor UCLA Medical Center, Torrance, California, 90509, USA

    Thuluvancheri K. Mohandas

  6. Istituto di Genetica, Universita di Bari, Bari, 70126, Italy

    Mariano Rocchi

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Schaefer, L., Ferrero, G., Grillo, A. et al. A high resolution deletion map of human chromosome Xp22. Nat Genet 4, 272–279 (1993). https://doi.org/10.1038/ng0793-272

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