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Sending out an SOS

Noonan syndrome is a disease caused by aberrant signaling through the Ras GTPase, yet the underlying causal mutations remain unknown in many affected individuals. Two papers now identify gain-of-function mutations in the Ras nucleotide exchange factor SOS1 as a new player in this common developmental disorder.

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Figure 1: Molecular genetics of Noonan syndrome.

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Shannon, K., Bollag, G. Sending out an SOS. Nat Genet 39, 8–9 (2007). https://doi.org/10.1038/ng0107-8

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