The insulin- and growth factor-stimulated protein kinases protein kinase B (PKB)/Akt and p70 S6 ribosomal kinase (S6K) are crucial regulators of cell growth. Recent advances, supported by work in this issue of Nature Cell Biology, have indicated that the tumour suppressor tuberous sclerosis complex-2 (TSC2) functions as an antagonist of S6K activation, an inhibition that is relieved by PKB-mediated phosphorylation of TSC2. In contrast to some previous models, these findings indicate that PKB functions upstream of S6K.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish
Journal of Hematology & Oncology Open Access 05 March 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kozma, S. C. & Thomas, G. Bioessays 24, 65–71 (2002).
Radimerski, T. et al. Nature Cell Biol. 4, 251–255 (2002).
Alessi, D. R. Biochem. Soc. Trans. 29, 1–14 (2001).
Ferrus, A. & Garcia-Bellido, A. Nature 260, 425–426 (1976).
Ito, N. & Rubin, G. M. Cell 96, 529–539 (1999).
Gomez, M., Sampson, J. & Whittemore, V. in The Tuberous Sclerosis Complex (Oxford University Press, Oxford, UK, 1999).
Gao, X. & Pan, D. Genes Dev. 15, 1383–1392 (2001).
Potter, C. J., Huang, H. & Xu, T. Cell 105, 357–368 (2001).
Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E. & Hariharan, I. K. Cell 105, 345–355 (2001).
Gao, X. et al. Nature Cell Biol. 4, 699–704 (2002).
Inoki, K., Li, Y., Zhu, T., Yu, J. W. & Guan, K. Nature Cell Biol. 4, 648–657 (2002).
Potter, C. J., Pedraza, L. G. & Xu, T. Nature Cell Biol. 4, 658–665 (2002).
Goncharova, E. A. et al. J. Biol. Chem. [online] (cited June 3 2002) 〈jbc.M202678200〉 (2002).
Jaeschke, A. et al. J. Cell Biol. (in the press).
Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J. & Cantley, L. C. Mol. Cell 10, 151–162 (2002).
Kwiatkowski, D. J. et al. Hum. Mol. Genet. 11, 525–534 (2002).
Lawlor, M. A. & Alessi, D. R. J. Cell Sci. 114, 2903–2910 (2001).
Wang, X. et al. EMBO J. 20, 4370–4379 (2001).
Burgering, B. M. & Coffer, P. J. Nature 376, 599–602 (1995).
Dufner, A., Andjelkovic, M., Burgering, B. M., Hemmings, B. A. & Thomas, G. Mol. Cell. Biol. 19, 4525–4534 (1999).
Williams, M. R. et al. Curr. Biol. 10, 439–448 (2000).
Biondi, R. M. et al. EMBO J. 21, 4219–4228 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McManus, E., Alessi, D. TSC1–TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol 4, E214–E216 (2002). https://doi.org/10.1038/ncb0902-e214
Issue Date:
DOI: https://doi.org/10.1038/ncb0902-e214
This article is cited by
-
Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish
Journal of Hematology & Oncology (2014)
-
Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle
Diabetologia (2012)
-
Royalactin induces queen differentiation in honeybees
Nature (2011)
-
Signal transduction molecules in gliomas of all grades
Journal of Neuro-Oncology (2009)
-
Lymphangioleiomyomatosis and Tuberous Sclerosis Complex
Lung (2008)
