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Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

Abstract

GENOMIC imprinting has been implicated in the onset of several embryonal tumours but the mechanism is not well understood1–3. Maternal chromosome 11p15 loss of heterozygosity4 and paternal chromosome 11 isodisomy5,6 suggest that imprinted genes are involved in the onset of Wilms' tumour and the Beckwith–Wiedemann syndrome. The insulin-like growth factor II (IGF2) gene located at 11pl5.5 has been put forward as a candidate gene as it is maternally imprinted (paternally expressed) in the mouse7, and is expressed at high levels in Wilms' tumours8,9. We report here that the IGF2 gene is expressed from the paternal allele in human fetal tissue, but that in Wilms' tumour expression can occur biallelically. These results provide, to our knowledge, the first evidence that relaxation of imprinting may play a role in the onset of disease and suggest a new genetic mechanism involved in the development of cancer.

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References

  1. Wilkins, R. J. The Lancet i, 329–331 (1988).

    Article  Google Scholar 

  2. Reik, W. & Surani, M. A. Nature 338, 112–113 (1989).

    Article  CAS  ADS  Google Scholar 

  3. Ponder, B. Nature 340, 264 (1989).

    Article  CAS  ADS  Google Scholar 

  4. Junien, C., Van Heyningen, V., Evans, G., Little, P. & Mannens, M. Genomics 12, 620–625 (1992).

    Article  CAS  Google Scholar 

  5. Henry, I. et al. Nature 351, 665–667 (1991).

    Article  CAS  ADS  Google Scholar 

  6. Grundy, P. et al. The Lancet 338, 1079–1080 (1991).

    Article  CAS  Google Scholar 

  7. DeChiara, M., Robertson, E. J. & Efstratiadis, A. Cell 64, 849–859 (1991).

    Article  CAS  Google Scholar 

  8. Reeve, A. E., Eccles, M. R., Wilkins, R. J., Bell, G. I. & Millow, L. J. Nature 317, 258–260 (1985).

    Article  CAS  ADS  Google Scholar 

  9. Scott, J. et al. Nature 317, 261–262 (1985).

    ADS  Google Scholar 

  10. Tadokoro, K., Fujii, H., Inoue, T. & Yamada, M. Nucleic Acids Res. 19, 6967 (1991).

    Article  CAS  Google Scholar 

  11. DeChiara, T. M., Efstradiadis, A. & Robertson, E. J. Nature 345, 78–80 (1990).

    Article  CAS  ADS  Google Scholar 

  12. Little, M., van Heyningnen, V. & Hastie, N. Nature 351 609–610 (1991).

    Article  CAS  ADS  Google Scholar 

  13. Olshan, A. F. Cander Genet. Cytogenet. 21, 303–307 (1986).

    Article  CAS  Google Scholar 

  14. Reik, W. Trends Genet. 5, 331–336 (1989).

    Article  CAS  Google Scholar 

  15. Moore, T. & Haig, D. Trends Genet. 7, 45–49 (1991).

    Article  CAS  Google Scholar 

  16. Ferguson-Smith, A. C., Cattanach, B. M., Barton, S. C., Beechey, C. V. & Surani, M. A. Nature 351, 667–670 (1991).

    Article  CAS  ADS  Google Scholar 

  17. Koufos, A. et al. Am. J. Hum. Genet. 44, 711–719 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Aleck, K. A. & Hadro, T. A. Am. J. med. Genet. 33, 155–160 (1989).

    Article  CAS  Google Scholar 

  19. Moutou, C., Junien, C., Henry, I. & Bonaiti-Pellie, C. J. Med. Genet. 29, 217–220 (1992).

    Article  CAS  Google Scholar 

  20. Vijoen, D. & Ramesar, R. J. med Genet. 29, 221–225 (1992).

    Article  Google Scholar 

  21. Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning: A Laboratory Manual 2nd edn (Cold Spring Harbor Laboratory Press, New York, 1989).

    Google Scholar 

Download references

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Ogawa, O., Eccles, M., Szeto, J. et al. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature 362, 749–751 (1993). https://doi.org/10.1038/362749a0

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