Abstract
THE NF-κB subunits pSO and p65 and the product of the rel proto-oncogene are members of a growing class of transcription factors with a unique DNA-binding and dimerization domain1–13. Nuclear transfer of each of these factors is controlled by cytoplasmic inhibitors, and regulated by specific stimuli. The inhibitors 1κB-α and -β and pp40 recognize either p65 or the c-rel protein14–16. We show here that the proto-oncogene bcl-3, believed to be involved in certain human B-cell leukaemias17, encodes a protein that functions as an IκB-like molecule for native NF-κB but is specific for the p50 subunit. The ankyrin repeat domain of the bcl-3 product is shown to mediate complex formation with NF-κB dimers by contacting the conserved dimerization domain of NF-κB.
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References
Wilhelmsen, K. E., Eggleton, K. & Temin, H. M. J. Virol. 52, 172–182 (1984).
Steward, R. Science 238, 692–694 (1987).
Bours, V., Villalobos, J., Burd, P. R., Kelley, K. & Siebenlist, U. Nature 348, 76–80 (1990).
Gosh, S. et al. Cell 62, 1019–1029 (1990).
Kieran, M. et al. Cell 62, 1007–1018 (1990).
Meyer, R. et al. Proc. natn. Acad. Sci. U.S.A. 88, 966–970 (1991).
Nolan, G. P., Ghosh, S., Liou, H.-C., Tempst, P. & Baltimore, D. Cell 64, 961–969 (1991).
Ruben, S. M. et al. Science 251, 1490–1493 (1991).
Schmid, R. M., Perkins, N. D., Duckett, C. S., Andrews, P. C. & Nabel, G. J. Nature 352, 733–736 (1991).
Neri, A. et al. Cell 67, 1075–1087 (1991).
Ryseck, R.-P. et al. Molec. cell. Biol. 12, 674–684 (1992).
Lenardo, M. J. & Baltimore, D. Cell 58, 227–229 (1989).
Gilmore, T. D. Cell 62, 841–843 (1990).
Davis, N. et al. Science 253, 1268–1271 (1991).
Kerr, L. D. et al. Genes Dev. 5, 1464–1476 (1991).
Zabel, U. & Baeuerle, P. A. Cell 61, 255–265 (1990).
Ohno, H., Takimoto, G. & McKeithan, T. W. Cell 60, 991–997 (1990).
Haskill, S. et al. Cell 65, 1281–1289 (1991).
Hatada, E. N. et al. Proc. natn. Acad. Sci. U.S.A. 89, 2489–2493 (1992).
Davis, L. H., Otto, E. & Bennett, V. J. biol. Chem. 266, 11163–11169 (1991).
Thompson, C. C., Brown, T. A. & McKnight, S. L. Science 253, 762–768 (1991).
Logeat, F. et al. EMBO J. 10, 1827–1832 (1991).
Inoue, J.-I., Kerr, L. D., Kakizuka, A. & Verma, I. M. Cell 68, 1109–1120 (1992).
Kawakami, K., Scheidereit, C. & Roeder, R. G. Proc. natn. Acad. Sci. U.S.A. 85, 4700–4704 (1988).
Ip, Y. T., Kraut, R., Levine, M. & Rushlow, C. S. Cell 64, 439–446 (1991).
Dignam, J. D., Lebowitz, R. M. & Roeder, R. G. Nucleic Acids Res. 11, 1475–1489 (1983).
Pognonec, P., Kato, H., Sumimoto, H., Kretschmar, M. & Roeder, R. G. Nucleic Acids Res. 19, 6650 (1991).
Smith, D. B. & Johnson, K. S. Gene 67, 31–40 (1988).
Schägger, H. & von Jagow, G. Analyt. Biochem. 166, 368–379 (1987).
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Wulczyn, F., Naumann, M. & Scheidereit, C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB . Nature 358, 597–599 (1992). https://doi.org/10.1038/358597a0
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DOI: https://doi.org/10.1038/358597a0
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