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A rough guide to a smooth brain

Abstract

Lissencephaly is a devastating genetic disease of children that affects the embryonic development of the brain. It is caused by haploinsufficiency of the Lis1 gene product, which seems to be required for proper functioning of cytoplasmic dynein during neuronal proliferation, migration and morphogenesis.

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Figure 1: A rough guide to cytoplasmic dynein and dynactin (not all the components are listed or shown).

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Morris, R. A rough guide to a smooth brain. Nat Cell Biol 2, E201–E202 (2000). https://doi.org/10.1038/35041123

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