Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Time course of recruitment of FADD and caspase-8 to TRAIL receptors.
Figure 2: Impaired TRAIL-R2 signalling pathway in mutant Jurkat T-cell lines that are defective in caspase-8 or FADD expression.

References

  1. Ashkenazi, A. & Dixit, V. M. Science 281, 1305–1308 (1998).

    Article  CAS  Google Scholar 

  2. Wiley, S. R. et al. Immunity 3, 673–682 (1995).

    Article  CAS  Google Scholar 

  3. Pan, G. et al. Science 276, 111–113 (1997).

    Article  CAS  Google Scholar 

  4. Pan, G. et al. Science 277, 815–818 (1997).

    Article  CAS  Google Scholar 

  5. Schneider, P. et al. FEBS Lett. 416, 329– 334 (1997).

    Article  CAS  Google Scholar 

  6. Sheridan, J. P. et al. Science 277, 818–821 (1997).

    Article  CAS  Google Scholar 

  7. Screaton, G. R. et al. Curr. Biol. 7, 693– 696 (1997).

    Article  CAS  Google Scholar 

  8. Walczak, H. et al. EMBO J. 16, 5386–5397 (1997).

    Article  CAS  Google Scholar 

  9. MacFarlane, M. et al. J. Biol. Chem. 272, 25417– 25420 (1997).

    Article  CAS  Google Scholar 

  10. Yeh, W. C. et al. Science 279, 1954– 1958 (1998).

    Article  CAS  Google Scholar 

  11. Wang, J. et al. Cell 98, 47–58 (1999).

    Article  CAS  Google Scholar 

  12. Kischkel, F. C. et al. EMBO J. 14, 5579–5588 (1995).

    Article  CAS  Google Scholar 

  13. Schneider, P. et al. J. Exp. Med. 187, 1205– 1213 (1998).

    Article  CAS  Google Scholar 

  14. Schneider, P. et al. Immunity 7, 831–836 (1997).

    Article  CAS  Google Scholar 

  15. Juo, P., Kuo, C. J., Yuan, J. & Blenis, J. Curr. Biol. 8, 1001–1008 (1998).

    Article  CAS  Google Scholar 

  16. Wajant, H. et al. Curr. Biol. 8, 113– 116 (1998).

    Article  CAS  Google Scholar 

  17. Irmler, M. et al. Nature 388, 190–195 (1997).

    Article  CAS  Google Scholar 

  18. Juo, P. et al. Cell Growth Differ. 10, 797– 804 (1999).

    CAS  PubMed  Google Scholar 

  19. Bordier, C. J. Biol. Chem. 256, 1604–1607 (1981).

Download references

Acknowledgements

We thank S. Masina and M. Thome for critical reading of the manuscript and for discussions, and S. Aslan for editorial assistance. This work was supported by grants from the Swiss National Science Foundation (to J.T.).

Correspondence and requests for materials should be addressed to J.T.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jürg Tschopp.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bodmer, JL., Holler, N., Reynard, S. et al. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2, 241–243 (2000). https://doi.org/10.1038/35008667

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/35008667

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing