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Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

Nature volume 342, pages 238–243 (1989)Cite this article

Abstract

Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

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Authors and Affiliations

  1. Sections on Molecular Neurogenetics and Molecular Pharmacology, Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland, 20892, USA

    John R. Kelsoe, Edward I. Ginns, Robert T. Long, Giovanni Conte & Steven M. Paul

  2. Department of Psychiatry, University of Miami School of Medicine, Miami, Florida, 33101, USA

    Janice A. Egeland

  3. Department of Genetics, Washington University School of Medicine, St Louis, Missouri, 63110, USA

    Daniela S. Gerhard

  4. Family Studies Section, Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Alisa M. Goldstein & Sherri J. Bale

  5. Child Study Center and Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    David L. Pauls

  6. Department of Human Genetics and Psychiatry, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Kenneth K. Kidd

  7. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    David E. Housman

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  1. John R. Kelsoe
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  2. Edward I. Ginns
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Kelsoe, J., Ginns, E., Egeland, J. et al. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342, 238–243 (1989). https://doi.org/10.1038/342238a0

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