Research Update
PAAD – a new protein domain associated with apoptosis, cancer and autoimmune diseases

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Abstract

A new protein domain was found in several proteins involved in apoptosis, inflammation, cancer and immune responses. Its location within these proteins and predicted fold suggests that it functions as a protein–protein interaction domain, possibly uniting different signaling pathways.

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Acknowledgements

We thank Dr Weizhong Li for the continuous development of the Saturated BLAST program. K.P. and A.G. were supported by NIH grant GM60049.

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