Neuron
Volume 37, Issue 1, 9 January 2003, Pages 7-10
Journal home page for Neuron

Minireview
Pathways to Parkinsonism

https://doi.org/10.1016/S0896-6273(02)01166-2Get rights and content
Under an Elsevier user license
open archive

Abstract

A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, α-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.

Cited by (0)