Elsevier

Genomics

Volume 18, Issue 3, December 1993, Pages 709-711
Genomics

Short communication
A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region*

https://doi.org/10.1016/S0888-7543(05)80380-5Get rights and content
Under a Creative Commons license
open archive

Abstract

A novel human gene (sazD) that maps to the autosomaldominant polycystic kidney disease region shares sequence similarity with members of the β-transducin superfamily. The cDNA sazD-c predicts an ∼58-kDa protein (sazD) with seven internal repeats, similar to the WD-40 motif of the transducin family. The size of this protein family has been expanding rapidly; however, neither the structure nor the function of this repeated motif is known. Preliminary data do not suggest that sazD is mutated in patients with polycystic kidney disease.

Cited by (0)

*

Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. U02609.

1

Current address: Division of Nephrology, Johns Hopkins UniversitySchool of Medicine, Baltimore, MD 21218.

2

Current address: Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10467.