Elsevier

Genomics

Volume 14, Issue 4, December 1992, Pages 988-994
Genomics

Linkage of usher syndrome type I gene (USH1B) to the long arm of chromosome 11

https://doi.org/10.1016/S0888-7543(05)80121-1Get rights and content

Usher syndrome is the most commonly recognized cause of combined visual and hearing loss in technologically developed countries. There are several different types and all are inherited in an autosomal recessive manner. There may be as many as five different genes responsible for at least two closely related phenotypes. The nature of the gene defects is unknown, and positional cloning strategies are being employed to identify the genes. This is a report of the localization of one gene for Usher syndrome type I to chromosome 11q, probably distal to marker D11S527. Another USH1 gene had been previously localized to chromosome 14q, and this second localization establishes the existence of a new and independent locus for Usher syndrome.

References (31)

  • JunienC. et al.

    Report of the committee on the genetic constitution of chromosome 11

    Cytogenet. Cell Genet.

    (1991)
  • KaplanJ. et al.

    Usher syndrome type I is not linked to D1S81 (pTHH 33):Evidence for genetic heterogeneity

    Ann. Genet.

    (1990)
  • KaplanJ. et al.

    Probable location of Usher type I gene on chromosome 14q by linkage with D14S13 (MLJ14 probe)

    Cytogenet. Cell Genet.

    (1991)
  • Keats, B. J. B., Todorov, A. A., Atwood, L. D., Pelias, M. Z., Hejtmancik, J. F., Kimberling, W. J., Leppert, M.,...
  • KikuchiK. et al.

    The development of the organ of Corti in the mouse

    Acta Otolaryngol.

    (1965)
  • Cited by (138)

    • USH1A: Chronicle of a slow death

      2006, American Journal of Human Genetics
    • Retinitis Pigmentosa and Allied Disorders

      2005, Retina: Fourth Edition
    View all citing articles on Scopus
    View full text