Five types of pyloric cells in the antral mucosa of the stomach

https://doi.org/10.1016/S0344-0338(11)81173-8Get rights and content

Summary

Only one type of pyloric cells in the exocrine antral glands is usually described in the literature. The review of 100 gastrectomy specimens revealed S types of pyloric cells: one composed of “ordinary” pyloric cells (i.e. cuboidal cells with ill-defined borders, pale, bubbly cytoplasm with an unconspicous cytoplasmic network).

The second type was characterized by pyloric cells with a small, regular vacuole, usually in a subnuclear position. The vacuole in such cells was negative for mucous stains. The third type of pyloric cells had a large intracytoplasmatic vacuole. Cells with this characteristic were found in cystically dilated pyloric glands. The vacuoles in such cells were usually negative for mucous stains although a rim of PAS or alcian blue positive substance was found in some vacuoles. The fourth type of pyloric cells had eosinophilic granules in the cytoplasm. These granules were proven to contain lysozyme. The fifth type had a non-vacuolated, homogenous (“glassy”) cytoplasm which was weakly positive for PAS but negative for acid mucines or mannosides. While the significance of the various types of pyloric cells herein described remains unclear, their easy identification in H & E stained preparations would permit more elaborated studies with histochemistry, immunoh isto chemistry and/or transmission electron microscopy in the future.

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1 This study was supported by grants from the Swedish Cancer Society, the Cancer Society in Stockholm and the Karolinska Institute.

2 Dedicated to Dr. Teruyuki Hirota on the occasion of his 60th birthday.

*

C. A. Rubio, Department of Pathology, Karolinska Institute, Stockholm, Swede

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