Letter To NeuroscienceDominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease
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Animals
All the animal experiments were performed according to institutional guidelines, and every effort was made to minimize animal suffering and to keep the number of animals used to a minimum. The generation of E3/0 and E4/0 mice has been described.2 E3/E4 mice were generated by crossing E3/0 with E4/0 mice. E3/0, E4/0, and 0/0 mice were obtained from the same crosses. Homozygous mice (E3/E3 or E4/E4) were obtained by crossing hemizygous mice of the same genotype. All mice were C57BL/6J and Apoe-/-
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2010, Trends in Molecular MedicineCitation Excerpt :The increased production of APOE3, but not APOE4, in the hippocampus stimulates the repair of local lesion-induced damage [56]. Moreover, synaptic and dendritic alterations and significant learning deficits, all of which associate with local neurite remodeling, are observed in ApoE-deficient mice [57] and APOE4 transgenic mice [58–63]. Notably, APOE3, but not APOE4, protects against excitotoxin-induced neuronal damage in mice [58].