Elsevier

Neuroscience Letters

Volume 277, Issue 1, 17 December 1999, Pages 65-67
Neuroscience Letters

Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

https://doi.org/10.1016/S0304-3940(99)00827-7Get rights and content

Abstract

We compared the distribution of an insertion (I)/deletion (D) polymorphism of the gene coding for the angiotensin-converting enzyme (ACE) in 133 Japanese sporadic Alzheimer disease (AD) patients with 257 controls. The association between AD and ACE genotypes or alleles was found to be significant. The frequency of II genotypes was 1.4 times higher in AD than controls, while that of DD genotypes was only 0.4 times as high. The altered distribution of ACE alleles in patients with AD appeared to be independent of apolipoprotein E.

References (20)

There are more references available in the full text version of this article.

Cited by (0)

View full text