Pustulosis palmaris et plantaris: Its association with chronic recurrent multifocal osteomyelitis*
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Cited by (83)
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with a cervical vertebral fracture: A case report
2021, North American Spine Society JournalCitation Excerpt :Theories involving bacteriologic, immunologic, and genetic factors have been proposed but none is universally accepted [22–24]. Palmoplantar pustulosis (PPP) is the most common skin manifestations and is seen in over 50% of patients diagnosed with SAPHO syndrome [14,15,25–27]. However, the correlation between cutaneous and musculoskeletal lesions is variable.
Chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO)
2021, Journal of Translational AutoimmunityAutoinflammatory diseases affecting bone and joints, and autoinflammatory interferonopathies
2020, Stiehm's Immune Deficiencies: Inborn Errors of ImmunityRadionuclide Imaging of Infection and Inflammation in Children: a Review
2018, Seminars in Nuclear MedicineCitation Excerpt :Other clinical features of this entity include multi-site involvement; multiple exacerbations with pain, swelling, and erythema at both initially involved as well as new sites; and a chronic, often protracted course.86,87 CRMO may be accompanied by a variety of skin disorders that may recur with the osseous exacerbations.88,89 Although initially described under the name “subacute and chronic recurrent osteomyelitis,”90 this non-infectious entity is distinctly different from bacterial osteomyelitis.
SAPHO and Recurrent Multifocal Osteomyelitis
2017, Radiologic Clinics of North AmericaCitation Excerpt :Likewise, in CRMO, antibiotics have proved to be an ineffective treatment option.43,50,54 This disappointing response to antibiotic therapy has led to more recent theories proposing that the P acnes bacterium may simply be the trigger for an autoimmune inflammatory cascade in these patients, with the osteoarticular changes being a result of the inflammatory reaction, rather than the bacteria itself.53,117,118,122–125 The main cytokines implicated in this response are TNF-α and various interleukins (IL), including IL-1, IL-6, IL-8, and IL-18.117,122,124,126–128
Chronic Recurrent Multifocal Osteomyelitis and Related Disorders
2016, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :Many individuals with CRMO also have a personal history of inflammatory disorders of the skin, intestine, joints, or other tissues. The strongest association is between CRMO and inflammatory skin conditions including palmoplantar pustulosis [49,91,94–98], psoriasis vulgaris [49,91,98,99], severe acne [49,91,100,101], generalized pustulosis [71], pyoderma gangrenosum [22,102,103], Sweet syndrome [57,61,104,105], and panniculitis [91]. Inflammatory bowel disease occurs in approximately 10% of individuals with CRMO, most often Crohn's disease, but ulcerative colitis and celiac disease also occur [5,22,26,49,106–115].
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From the Divisions of Dermatology, Immunology and Pathology, Children's Memorial Hospital.