Cell
Volume 111, Issue 3, 1 November 2002, Pages 281-284
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Epigenetic Consequences of Nucleosome Dynamics

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Abstract

Current models for epigenetic gene silencing envision a static relationship between histone modifications and transcription. However, evidence for nucleosome mobility and replacement favors a dynamic model that may explain phenomena ranging from variegation to the neural restriction of Rett syndrome.

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Present address: BCMP Department, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115.