Original ArticlesVariation in the Incidence of Uterine Leiomyoma Among Premenopausal Women by Age and Race☆
Section snippets
Materials and Methods
The Nurses’ Health Study II cohort formed in September 1989 when 116,678 registered female nurses age 25–42 years from 14 states in the United States returned mailed questionnaires regarding age, race, height, weight at age 18, current weight, age at menarche, pregnancy history, history of oral contraceptive use, menopausal status, history of cigarette smoking, current alcohol consumption, and leisure-time physical activity. New questionnaires are mailed every two years to update this
Results
During 327,065 woman-years of follow-up, 4181 incident cases of uterine leiomyoma were reported. Of these, 667 (16%) were confirmed at hysterectomy, 2339 (56%) at ultrasound, and 1175 (28%) at pelvic examination only. The crude incidence rates per 1000 woman-years were 12.8 for all diagnoses of uterine leiomyoma, 9.2 for diagnoses confirmed at ultrasound or hysterectomy, and 2.0 for diagnoses confirmed at hysterectomy. Incidence rates increased with age (Table 1).
The incidence rates of uterine
Discussion
In these prospective data, we observed the incidence rates of uterine leiomyoma among premenopausal women to be associated strongly with age and approximately two to three times greater among black women than among white women. The excess rates were not attributable to a higher prevalence of risk factors among black women, nor were they attributable to differences in health screening practices, as measured by a recent physical examination or Papanicolaou smear, among the racial groups in this
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Supported by Public Health Research Grant RO1-50385 from the National Institutes of Health and in part by a National Institutional Research Service Award (ES07069) from the National Institute of Environmental Health Sciences (to Dr. Marshall), Faculty Research Awards (FRA-398 and FRA-455) from the American Cancer Society (to Dr. Colditz and Dr. Hunter), and a grant from the Henry J. Kaiser Family Foundation (to Dr. Goldman).