Original article
Predictive value of minor anomalies. I. Association with major malformations+

https://doi.org/10.1016/S0022-3476(87)80543-7Get rights and content

We examined 4305 white newborn infants for 114 minor physical features and major malformations to evaluate the hypothesis that the presence of three or more minor anomalies is highly predictive of a major malformation. We confirmed that the infant with three or more minor anomalies is at increased risk for a major malformation. However, this risk (19.6%) was much lower than the risk of 90% popularized by Smith and based on the study of Marden et al. (J Pediatr 1964;64:357). Analysis of the findings in the two studies showed that the lower predictive value was probably related to differences in study design. Nevertheless, some minor anomalies remain essential to the early recognition of several serious malformation syndromes.

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Supported in part by grants from the Developmental Disabilities Council of the Commonwealth of Massachusetts, by Grant 10910 from the National Institutes of Health, and by a grant from Merrell Dow Pharmaceuticals, Inc.

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