Original article
Trisomy 13 (D1) syndrome: Studies on parentalage, sex ratio, and survival***

https://doi.org/10.1016/S0022-3476(68)80072-1Get rights and content

A group of 221 patients with chromosomally proved trisomy 13 syndrome were analyzed in regard to survival, sex ratio, and parental age. Approximately one half lived to 1 month, one third to 3 months, and one twentieth to 3 years of age. Patients with translocation or mosaicism had a somewhat longer survival than those with trisomy. The sex ratio disclosed a slight excess of females born with trisomy and remained constant among survivors at later ages. The maternal ages of patients with trisomy described a bimodal distribution, consistent with age-independent and age-dependent subgroups. The maternal ages of those with translocation corresponded to the first peak, indicating that in this syndrome translocations occur independently of maternal age.

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***

Supported by grants from the National Institutes of Health (H 3091 at the University of Washington, CA 09471 at the University of Oregon Medical School, and CH 0080 at the New York State Department of Health) and from the Children's Bureau to the Crippled Children's Division for a Genetic Program.

*

University of Oregon Medical School.

***

Present address: University of Hawaii.

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