Pattern formation and developmental mechanismVertebrate limb development
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Positional information and pattern formation
Curr Top Dev Biol
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FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
Cell
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Sonic hedgehog mediates the polarizing activity of the ZPA
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The mouse Fgf-8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
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Drosophila hedgehog acts as a morphogen in cellular patterning
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Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximo-distal and dorsoventral axes
Mech Dev
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Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth
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Fibroblast growth factors induce additional limb development from the flank of chick embryos
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FGF-2: apical ectodermal ridge outgrowth signal for chick limb development
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Products, genetic linkage and limb patterning activity of a murine hedgehog gene
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Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb
Nature
Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system
Mech Dev
Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung
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Retinoic acid, local cell-cell interactions, and pattern formation in vertebrate limbs
Dev Biol
Cited by (151)
Reactivation of larval keratin gene (krt62.L) in blastema epithelium during Xenopus froglet limb regeneration
2017, Developmental BiologyCitation Excerpt :Dependence of an AEC on Fgf-signaling seems likely, since an AEC has been considered to be similar in structure to an apical ectodermal ridge (AER), which is located on the very distal tip of developing limb buds in amniotes and plays an essential role in limb development (Makanae and Satoh, 2012; Nye et al., 2003). The AER is well characterized, and its Fgf-signaling dependence is apparent (Tickle, 1995). As is the case with the AER, fgf8 expression of the AEC was maintained by Fgf-signaling (Fig. 5B).
Developmental Basis of Congenital Limb Differences
2011, Fetal and Neonatal Physiology E-Book, Fourth EditionFunctional alterations in mechanical loading of condylar cartilage induces changes in the bony subcondylar region
2009, Archives of Oral BiologyCitation Excerpt :In vivo bone remodeling involves the recruitment and replication of mesenchymal precursors of osteoblasts, their differentiation into pre-osteoblasts, osteoblasts and mature osteoblasts, ultimately resulting in the accumulation and mineralization of the extracellular matrix. During the initial development of the vertebrate skeleton, the mesenchyme receives patterning signals that determine the shape, size and number of mesenchymal condensations.2 With the exception of the cranial base synchondroses and the temporomandibular joints (TMJs), all the articulations between the bones of the skull are fibrous joints.
Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb
2007, Developmental BiologyMechanistic insight into how Shh patterns the vertebrate limb
2006, Current Opinion in Genetics and DevelopmentSelective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation
2005, Journal of Biological Chemistry