Novel approaches to linkage mapping

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Abstract

The recent progress seen in the development of high-quality genetic markers and high-density human genetic maps is facilitating new strategies for mapping disease-causing and disease-susceptibility genes. These strategies, which include homozygosity mapping, DNA pooling, and the utilization of linkage disequilibrium, have been successfully applied to the mapping and fine mapping of several loci causing diseases segregating in genetically isolated populations.

References (49)

  • JC Murray et al.

    A comprehensive human linkage map with centimorgan density

    Science

    (1994)
  • WF Dietrich et al.

    A genetic map of the mouse with 4,006 simple sequence length polymorphisms

    Nature Genet

    (1994)
  • J Dubovsky et al.

    Sets of short tandem repeat polymorphisms for efficient linkage screening of the human genome

    Hum Mol Genet

    (1995)
  • JS Ziegle et al.

    Application of automated DNA sizing technology for genotyping microsatellite loci

    Genomics

    (1992)
  • PW Reed et al.

    Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping

    Nature Genet

    (1994)
  • DA Schwengel et al.

    Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques

    Genomics

    (1994)
  • AE Garrod

    The Croonian lectures on inborn errors of metabolism. Lecture II Alkaptonuria

    Lancet

    (1908)
  • C Smith

    The detection of linkage in human genetics

    J Roy Stat Soc B

    (1953)
  • MR Pollak et al.

    Homozygosity mapping of the gene fo alkaptonuria to chromosome 3q2

    Nature Genet

    (1993)
  • AE Kwitek-Black et al.

    Linkage of Bardet-Biedl syndrome to chromosome 16q and evidence for non-allelic genetic heterogeneity

    Nature Genet

    (1993)
  • C Ben Hamida et al.

    Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping

    Nature Genet

    (1993)
  • M Goto et al.

    Genetic linkage of Werner's syndrome to five markers on chromosome 8

    Nature

    (1992)
  • AHM Burghes et al.

    Linkage mapping of the spinal muscular atrophy gene

    Hum Genet

    (1994)
  • P Guilford et al.

    A human gene responsible for neurosensory, non-syndromic recessive deafness is a candidate homologue of the mouse sh-1 gene

    Hum Mol Genet

    (1994)

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