Reproductive fitness in familial schizophrenia☆
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Cited by (68)
Schizophrenia: The new etiological synthesis
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The problem arises when schizotypy (as a fast life history strategy trait) becomes pathological, reducing reproductive success as a result of the interaction among developmental perturbances, genetic mutations, parasitic infections, nutritional deficits, and/or stressful situations in vulnerable individuals (Brüne et al., 2010; Del Giudice et al., 2014). These hypotheses are undermined by the fact that individuals with schizophrenia show very low reproductive success relative to controls (about 0.3–0.8 on average) and that, contrary to predictions arising from an evolutionary biological sexual selection hypothesis, the reduction in fertility is more severe in male patients (Bassett et al., 1996; Haukka et al., 2003; MacCabe et al., 2009; Svensson et al., 2007). Thus, it is commonly thought that fertility in non-affected individuals is not high enough to offset the reproductive costs of schizophrenia, as would also be predicted based on the balanced polymorphism hypothesis.
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
2019, Schizophrenia ResearchCitation Excerpt :It occurs at quite similar rates across populations worldwide (Ayuso-Mateos, 2002; Brüne, 2004; WHO, 1973) and written records describing its symptoms exist dating back 5000 years (Jeste et al., 1985). This consistent persistence of the disease despite reduced fecundity (Brüne, 2004; Essen-Mӧller, 1959; Lewis, 1958; Macsorley, 1963; Nichols, 2009; Power et al., 2013; Stevens, 1969) and increased mortality is a paradox (Bassett et al., 1996; Brown, 1997; Larson and Nyman, 1973), since the reduced fecundity of patients afflicted with schizophrenia does not appear to eliminate the disease from the population (Power et al., 2013). Part of the reason may be due to afflicted individuals reproducing prior to the onset of the disease (Markow, 2012).
Schizophrenia and induced abortions: A national register-based follow-up study among Finnish women born between 1965–1980 with schizophrenia or schizoaffective disorder
2018, Schizophrenia ResearchCitation Excerpt :However, the changes in the general social and political climates and the development of the modern Nordic health-care system also resulted in a transformation of the legislation concerning induced abortion in 1970. In the present study with regard to medical indications, our hypothesis turned out to be only partly right: medical indication due to the mother-to-be was relatively rare, but was substantially more common in women with schizophrenia or schizoaffective disorder than in controls, presumably due to medication in use and/or the effects of the illness itself (Bassett et al., 1996). In contrast to this, medical indication due to the fetus turned out to be substantially more prevalent in controls than in women with schizophrenia or schizoaffective disorder.
From madness to genius: The Openness/Intellect trait domain as a paradoxical simplex
2012, Journal of Research in PersonalityCitation Excerpt :The identification of apophenia as a facet of Openness additionally may help to clarify evolutionary theories designed to explain the prevalence of schizophrenia. Schizophrenia itself is associated with reduced reproductive success and hence reduced fitness (Avila, Thaker, & Adami, 2001; Bassett, Bury, Hodgkinson, & Honer, 1996), a fact which makes its continued presence in the population puzzling, unless one posits the existence of selection for traits that create risk for schizophrenia. Openness has been hypothesized to be such a trait (Nettle, 2006a).
Brain disorder and rock art
2013, Cambridge Archaeological JournalThe EEG multiverse of schizophrenia
2023, Cerebral Cortex
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Presented in part at the Vth International Congress on Schizophrenia Research, Warm Springs, Virginia, April 8–12, 1995.