The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein

doi:10.1016/0896-6273(91)90122-G

Neuron

Volume 6, Issue 1, January 1991, Pages 61-70

https://doi.org/10.1016/0896-6273(91)90122-G Get rights and content

Abstract

Mice homozygous for the retinal degeneration slow (rds) mutation exhibit abnormal development of photoreceptor cells, followed by their slow degeneration. We have recently cloned the rds gene and determined the structure of the wild-type rds mRNA. Here we show that the gene is expressed exclusively in photoreceptor cells. We demonstrate that it encodes a 39 kd membrane-associated glycoprotein that is restricted to photoreceptor outer segments. By electron microscopy, we show that the rds protein is distributed uniformly within outer segment discs. The developmental appearance of the rds protein coincides with outer segment disc formation. We propose that the rds protein functions as an adhesion molecule for stabilization of the outer segment discs.

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Neuron

ArticleThe retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein

Abstract

J. Biol. Chem.

Biochim. Biophys. Acta

Exp. Eye Res.

Exp. Eye Res.

Biochim. Biophys. Acta

J. Mol. Biol.

Neurosci. Lett.

Neurosci. Lett.

Cell

Exp. Eye Res.

Anal. Biochem.

Nucleotide and predicted protein sequence of rat retinal degeneration slow (rds)

Nucl. Acids Res.

A diurnal rhythm in opsin content of Rana pipiens rod inner segments

Invest. Ophthalmol. Vis. Sci.

Differential effect of the rd mutation on rods and cones in the mouse retina

Invest. Ophthalmol. Vis. Sci.

Some cytological and initial biochemical observations on photoreceptors in retinas of rds mice

Invest. Ophthalmol. Vis. Sci.

Molecular cloning, primary structure and orientation of the vertebrate photoreceptor cell protein peripherin in the rod outer segment disk membrane

Biochemistry

Photoreceptor cell peripherin is the defective protein responsible for retinal degeneration slow (rds)

Invest. Ophthalmol. Vis. Sci.

endo-β-N-Acetylglucos-aminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high mannose and complex glycoproteins

Membrane morphogenesis in retinal rod outer segments: inhibition by tunicamycin

J. Cell Biol.

Article
The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein