Mapping of the human complement factor I gene to 4q25

doi:10.1016/0888-7543(89)90318-2

Genomics

Volume 4, Issue 1, January 1989, Pages 82-86

https://doi.org/10.1016/0888-7543(89)90318-2 Get rights and content

Abstract

A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.

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Mapping of the human complement factor I gene to 4q25

Abstract

Anal. Biochem

Anal. Biochem

Cytogenet. Cell Genet

Medicine

Clinical and cytogenetic survey of 39 individuals with Prader-Labhart-Willi syndrome

Amer. J. Med. Genet

Genetic counterselective procedure to isolate interspecific cell hybrids containing single human chromosomes: Construction of cell hybrids and recombinant DNA libraries specific for human chromosomes 3 and 4

Somat. Cell Mol. Genet

Mapping of steroid 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex in man

Immunological Diseases

A family with Huntington disease and reciprocal translocation 4;5

Amer. J. Hum. Genet

Human complement factor I: Analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4

J. Biol. Chem

“Elektrophorese” Forum

Strategies for multilocus linkage analysis in humans

An automated system of linkage analysis (Gene Mapping System or GMS)

Human Gene Mapping 9, Paris