Elsevier

Gene

Volume 151, Issues 1–2, 30 December 1994, Pages 339-340
Gene

Polymorphism of the gene encoding a human minimal potassium ion channel (minK)

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Abstract

A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which differs from the original sequence with a single A → G at position 112. This resulted in a change from a Ser codon (AGT) to a Gly codon (GGT) and created a new MspAI restriction site. Of the 32 alleles from 16 subjects studied, 25 had this newly discovered sequence and 7 had the previously described sequence.

Keywords

Long QT syndrome
gene sequence
restriction map

Abbreviations

aa
amino acid (s)
bp
base pair (s)
LQTS
long QT syndrome
minK
gene (cDNA) encoding minimal K+ channel
nt
nucleotide (s)
PCR
polymerase chain reaction

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On request, the authors will supply detailed experimental evidence for the conclusions reached in this Brief Note.