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Complement drives circuit modulation in the adult brain
2022, Progress in NeurobiologyPharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy
2013, Neurobiology of DiseaseCitation Excerpt :Considering that these pathways play a significant role in experimental seizure generation (Kharatishvili et al., 2013; Maroso et al., 2010; Sakatani et al., 2008; Shetty, 2011; Xiong et al., 2003), it is likely that their persisting activation has compensated for the IL-1β signaling blockade, therefore precluding any genuine antiepileptogenic effect. Complement upregulation may also account for cell loss in CA3 area where high level of neurotoxic C1q is induced by SE (Aronica et al., 2007; Rozovsky et al., 1994; Xiong et al., 2003). Moreover, TLRs activation per se sustains NF-kB-mediated transcription of inflammatory genes, including the IL-1β/IL-1R1 genes (O'Neill and Bowie, 2007; Vezzani et al., 2011b), likely explaining why the broad inflammatory cascade induced by SE was not affected by the combined treatment.
Inflammation and epilepsy
2012, Handbook of Clinical NeurologyCitation Excerpt :Among these inflammatory mediators, complement factors and COX-2 have been studied in more detail. In particular, the C1q factor of the complement cascade is upregulated by seizures in astrocytes, microglia, and neurons, and its expression is maintained in chronic epileptic tissue from animal models and human TLE (Rozovsky et al., 1994; Aronica et al., 2007). The membrane attack complex is also upregulated in microglia and surviving neurons in TLE (Aronica et al., 2007).
Complement in the brain
2011, Molecular ImmunologyInflammation in aging processes: An integrative and ecological perspective
2011, Handbook of the Biology of AgingTHE ROLE OF THE COMPLEMENT SYSTEM IN ALZHEIMER’S DISEASE
2023, Ankara Universitesi Eczacilik Fakultesi Dergisi