Apolipoprotein ϵ4 allele and disease progression in patients with late-onset Alzheimer's disease
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Cited by (88)
Consensus-based recommendations for the management of rapid cognitive decline due to Alzheimer's disease
2017, Alzheimer's and DementiaCitation Excerpt :Various lines of evidence indicate the impact of genetic biomarkers on the progression of cognitive decline in AD-related dementia [8], whereas it has not yet been established whether RCD occurs more commonly in early onset familial AD [9]. The association between the APOE ε4 allele and cognitive decline in patients with AD remains controversial [10–30]. In addition, the presence of the K and A variant alleles of the butyrylcholinesterase gene have been associated with slower cognitive decline in patients with severe AD [31,32].
Genetics of Alzheimer Disease
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsGenetic heterogeneity of Alzheimer's disease: Complexity and advances
2007, PsychoneuroendocrinologyCitation Excerpt :On the other hand, those with the ε4 allele were thought to have a lower mortality rate (van Duijn et al., 1995). Several studies further suggest that disease duration is longer in patients with an ε4 allele (Basun et al., 1995). These different observations have led some authors to hypothesize that the association between the ε4 allele and disease may be due simply to the longer disease duration in the cases, which thus induces an artificial increase in allele frequency in case–control studies.
The APOE gene and cognitive function in non-demented and Alzheimer's disease patients
2009, Reviews in Clinical Gerontology