Review
Transcriptional control of lymphoid development: lessons from gene targeting

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Abstract

Cis-acting control regions have been defined for many hematopoietic genes and used to identify DNA-binding factors. The orderly expression of these factors is hypothesized to control entry into and progression along the various differentiation pathways. Gene-knockout technology is now unveiling the essential functions of these candidate differentiation control factors. Here, Hans Clevers and Rudolf Grosschedl discuss the results and implications of a number of such gene-disruption experiments.

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    1

    H.C. is supported by a PIONIER grant from NWO.

    2

    R.G. is supported by the Howard Hughes Medical Institute.

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