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Neurofibromatosis in a man with a ring 22: In situ hybridization studies

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Abstract

In situ hybridization with a c-sis probe was performed on peripheral lymphocytes of a man with neurofibromatosis and a ring 22 chromosome. Hybridization was observed on both the normal #22 and the ring 22, indicating that the patient is not constitutionally hemizygous for c-sis. The implications of a ring 22 constitution and the neurofibromatosis phenotype are discussed.

References (15)

  • FW Crowe et al.

    A Clinical, Pathological and Genetic Study of Multiple Neurofibromatosis

    (1956)
  • A Spence et al.

    Linkage analysis of neurofibromatosis (Von Recklinghausen disease)

    J Med Genet

    (1983)
  • BG Dunn et al.

    A genetic linkage study of 15 families of individuals with Von Recklinghausen neurofibromatosis

    Am J Med Genet

    (1985)
  • DG Hope et al.

    Malignancy in neurofibromatosis

    Adv Neurol

    (1981)
  • SC Jhanwar et al.

    Localization of the cellular oncogenes ABL SIS and FES on human germ-line chromosomes

    Cytogenet Cell Genet

    (1984)
  • R Dalla-Favera et al.

    A human onc gene homologous to the transforming gene (v-sis) of simian sarcoma virus

    Nature

    (1981)
  • ME Harper et al.

    Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization

    Chromosoma

    (1981)
There are more references available in the full text version of this article.

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Supported in part by Grant 84-29 from The Hospital for Sick Children Foundation. Toronto.

1

A. M. V. D. is an Ontario Ministry of Health Cancer Scientist

2

D. S. was an Ontario Mental Health foundation research associate.

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