Research paperAbnormal lymphocyte subsets in Kuwaiti patients with type-1 insulin-dependent diabetes mellitus and their first-degree relatives
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2021, Molecular TherapyCitation Excerpt :Some reports indicate that a subject’s race may regulate certain immune cell subsets,25 but the immune cell proportions for the 12 healthy controls in this study were within the expected normal range of 1.5–2.5 despite the racial mix, indicating that race differences do not negate the finding of a difference in CD4/CD8 status and other immune subsets of the XLRS subjects at the pre-dosing baseline. Increased CD4/CD8 ratios generally are associated with conditions of chronic autoimmunity and inflammation.26–28 Dysregulation of the T cell ratio is reported for multiple sclerosis, sarcoidosis, and Alzheimer’s disease, and also in elderly subjects.29–31
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