Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy

doi:10.1016/0022-510X(88)90125-6

Journal of the Neurological Sciences

Volume 84, Issues 2–3, April 1988, Pages 201-208

https://doi.org/10.1016/0022-510X(88)90125-6 Get rights and content

Abstract

IFN-alpha was detected in cerebrospinal fluid and/or sera from 7 of 8 patients with a progressive familial encephalopathy associated with calcifications of the basal ganglia and white matter alterations. The secretion of IFN-alpha was prolonged, as shown by its presence at different times between birth and 5 years, and was not associated with IFN-gamma.

Virological investigations excluded various congenital infections. In only 2 patients, high levels of Epstein-Barr virus antibodies were observed, indicating the possibility of an abnormal response to viral infection rather than a congenital infection. Further investigations are required for characterization of the recessive autosomal trait of this syndrome and its relation to the IFN system.

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Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy

Abstract

A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis

Ann. Neurol.

Isolation of a T lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)

Science

Use of monoclonal antibodies as sensitive and specific probes for biologically active human gamma interferon

Acid-labile human leukocyte interferon in homosexual men with Kaposi Sarcoma and lymphadenopathy

J. Infect. Dis.

Intrathecal synthesis of different alpha-interferons in children with various neurological disorders

Acta. Neurol. Scand.

In utero Epstein-Barr virus (infectious mononucleosis) infection

J. Am. Med. Assoc.

Pronounced antiviral activity of human interferon on bovine and porcine cells

Nature

Prospective study of EBV infection during pregnancy

Biomedicine

Congenital infection with cytomegalovirus and Epstein-Barr virus

Can. Med. J.