Journal of Molecular Biology
Five SWI genes are required for expression of the HO gene in yeast☆
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2022, Developmental BiologyCitation Excerpt :Unlike PRC2, SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes utilize energies derived from ATP hydrolysis to remodel chromatin and regulate gene transcription (Hota and Bruneau, 2016). Their function to regulate inducible genes in mating-type switching (SWI) and growth on sucrose (sucrose non-fermentable, SNF) were initially identified in yeast (Neigeborn and Carlson, 1984; Peterson and Herskowitz, 1992; Stern et al., 1984). In Drosophila, SWI/SNF complexes control expression of homeotic genes by antagonizing polycomb activity to determine body segment identity during development (Elfring et al., 1994; Kennison and Tamkun, 1988; Tamkun et al., 1992).
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The research was supported by research grant AI-13462 from the Public Health Service.