Case report
Multiple lentigines syndrome: Case report and review of the literature

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Abstract

The multiple lentigines syndrome is reviewed and a new case is presented. The major features of this syndrome are lentigines and other cutaneous abnormalities, cardiac defects, neurologic defects, cephalofacial dysmorphism, shortness of stature, skeletal anomalies, genitourinary abnormalities, and a family history consistent with an autosomal dominant mode of inheritance. The multiple lentigines syndrome manifests markedly variable expressivity; no single finding is pathognomonic and few patients have all major features. We propose specific criteria for diagnosis.

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      Electrocardiograms of the son (proband) and daughter are presented in Figures 4 and 5; findings are presented in Table 1. Diagnostic criteria for LEOPARD syndrome were proposed by Voron et al in 1976 and include lentigines and 2 other recognized features of LEOPARD syndrome or a first-degree relative with lentigines and 3 other features in the patient.4 Typically, multiple lentigines appear during childhood and expand in number until puberty.5

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    1

    From the Dermatology and Endocrine-Metabolic Sections of the Department of Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin.

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