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Crohn’s-like Colitis in a Patient with Immunodeficiency Associated with a Defect in Expression of Inducible Costimulator

  • Inflammatory Bowel Disease
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References

  1. Shanahan F: Crohn’s disease. Lancet 359:62–69, 2002

    Article  CAS  PubMed  Google Scholar 

  2. Atreya R, Mudter J, Finotto S, et al.: Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 6:583–588, 2000

    CAS  PubMed  Google Scholar 

  3. MacDonald TT, Monteleone G, Pender SL: Recent developments in the immunology of inflammatory bowel disease. Scand J Immunol 51:2–9, 2000

    Article  CAS  PubMed  Google Scholar 

  4. Targan SR, Deem RL, Liu M, et al.: Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol 154:664–675, 1995

    CAS  PubMed  Google Scholar 

  5. Hutloff A, Dittrich AM, Beier KC, et al.: ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397:263–266, 1999

    CAS  PubMed  Google Scholar 

  6. Sato T, Kanai T, Watanabe M, et al.: Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. Gastroenterology 126:829–839, 2004

    Article  CAS  PubMed  Google Scholar 

  7. Cunningham-Rundles C: Common variable immunodeficiency. Curr Allergy Asthma Rep 1:421–429, 2001

    CAS  PubMed  Google Scholar 

  8. Grimbacher B, Hutloff A, Schlesier M, et al.: Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol 4:261–268, 2003

    Article  CAS  PubMed  Google Scholar 

  9. Meraz MA, White JM, Sheehan KC, et al.: Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431–442, 1996

    Article  CAS  PubMed  Google Scholar 

  10. Mudter J, Weigmann B, Bartsch B, et al.: Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. Am J Gastroenterol 100:64–72, 2005

    Article  CAS  PubMed  Google Scholar 

  11. Afkarian M, Sedy JR, Yang J, et al.: T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 3:549–557, 2002

    Article  CAS  PubMed  Google Scholar 

  12. Bastlein C, Burlefinger R, Holzberg E, et al.: Common variable immunodeficiency syndrome and nodular lymphoid hyperplasia in the small intestine. Endoscopy 20:272–275, 1988

    CAS  PubMed  Google Scholar 

  13. Rodriguez Maria R. [A patient with gastrointestinal manifestations and the common variable immunodeficiency syndrome]. Rev Esp Enferm Dig 86:679–681, 1994

    CAS  PubMed  Google Scholar 

  14. Heneghan MA, Stevens FM, Cryan EM, et al.: Celiac sprue and immunodeficiency states: a 25-year review. J Clin Gastroenterol 25:421–425, 1997

    Article  CAS  PubMed  Google Scholar 

  15. Byrne MF, Royston D, Patchett SE: Association of common variable immunodeficiency with atypical collagenous colitis. Eur J Gastroenterol Hepatol 15:1051–1053, 2003

    PubMed  Google Scholar 

  16. Washington K, Stenzel TT, Buckley RH, et al.: Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia. Am J Surg Pathol 20:1240–1252, 1996

    Article  CAS  PubMed  Google Scholar 

  17. Hammarstrom L, Vorechovsky I, Webster D: Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol 120:225–231, 2000

    Article  CAS  PubMed  Google Scholar 

  18. Pfluger H, Helbling A, Mordasini C, et al.: [CVID (common variable immunodeficiency): heterogeneous clinical manifestation of the commonest symptomatic primary immunodeficiency disease]. Schweiz Med Wochenschr 130:1590–1599, 2000

    CAS  PubMed  Google Scholar 

  19. Larvol L, Cervoni JP, Hagiage M, et al.: [Colonic lymphoma simulating cryptogenetic colitis associated with common variable hypogammaglobulinemia]. Gastroenterol Clin Biol 18:779–781, 1994

    CAS  PubMed  Google Scholar 

  20. Cunningham-Rundles C, Cooper DL, Duffy TP, et al.: Lymphomas of mucosal-associated lymphoid tissue in common variable immunodeficiency. Am J Hematol 69:171–178, 2002

    Article  CAS  PubMed  Google Scholar 

  21. Gompels MM, Hodges E, Lock RJ, et al.: Lymphoproliferative disease in antibody deficiency: a multi-centre study. Clin Exp Immunol 134:314–320, 2003

    Article  CAS  PubMed  Google Scholar 

  22. de Jong YP, Rietdijk ST, Faubion WA, et al.: Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis. Int Immunol 16:205–213, 2004

    PubMed  Google Scholar 

  23. Kanai T, Totsuka T, Tezuka K, et al.: ICOS costimulation in inflammatory bowel disease. J Gastroenterol 37 (Suppl 14):78–81, 2002

    CAS  PubMed  Google Scholar 

  24. Miyahira Y, Akiba H, Ogawa SH, et al.: Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett 89(2–3):193–199, 2003

    CAS  PubMed  Google Scholar 

  25. Vermeiren J, Ceuppens JL, Van Ghelue M, et al.: Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity. J Immunol 172(9):5371–5378, 2004

    CAS  PubMed  Google Scholar 

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Correspondence to Markus F. Neurath ProfMed.

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Mudter, J., Wirtz, S., Weigmann, B. et al. Crohn’s-like Colitis in a Patient with Immunodeficiency Associated with a Defect in Expression of Inducible Costimulator. Dig Dis Sci 51, 711–717 (2006). https://doi.org/10.1007/s10620-006-3196-x

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  • DOI: https://doi.org/10.1007/s10620-006-3196-x

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